Development of effective blood substitutes based on a deep understanding of the microcirculation. Applications to transfusion and emergency medicine, cancer, ischemia, and the heart-lung machine. Professor Intaglietta has largely influenced present understanding of the effects of viscosity and colloid osmotic pressure on the local regulation of blood flow and oxygen transport at the level of microscopic blood vessels. He is the author or co-author of more than 200 scientific papers and books and pioneered instruments currently in use in laboratories worldwide for studying the microcirculation. His fundamental discovery that oxygen is delivered in small pulses to the microcirculation has provided important information towards creating effective blood substitutes. Previously, substitutes actually caused blood vessels to constrict and shut down because the substitutes delivered too much oxygen. Intaglietta has also collaborated for many years with international colleagues in Europe, Latin America and Asia on projects related to blood plasma expanders for use in emergency situations and for companies with low blood bank supplies.
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